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NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells

Shohei Tsuji, Shinsuke Nakamura, Kenji Shoda, Tetsuya Yamada, Masamitsu Shimazawa, Noriyuki Nakayama, Toru Iwama, Hideaki Hara

2022Journal of Neuro-Oncology11 citationsDOI

Topics & Concepts

TemozolomideDownregulation and upregulationCancer researchGene knockdownNMDA receptorMethyltransferaseSmall hairpin RNACytotoxic T cellMemantineChemistryDNA methyltransferaseDNA repairPharmacologyDNA damageBiologyReceptorGliomaApoptosisDNABiochemistryIn vitroMethylationGeneGlioma Diagnosis and TreatmentEpigenetics and DNA MethylationChemical Reactions and Isotopes
NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells | Litcius