Mindin Activates Autophagy for Lipid Utilization and Facilitates White Spot Syndrome Virus Infection in Shrimp
Jie Gao, Ye-Jia Song, Hao Wang, Bao-Rui Zhao, Xian‐Wei Wang
Abstract
White spot syndrome virus (WSSV) is an enveloped double-stranded DNA virus that has had a serious influence on worldwide shrimp farming in the last 30 years. We have demonstrated that WSSV hijacks host autophagy and lipid metabolism for reproduction in kuruma shrimp ( Marsupenaeus japonicus ). These findings revealed the mechanism by which WSSV exploits host machinery for its infection and provided serial targets for WSSV prevention and control in shrimp farming.
Topics & Concepts
White spot syndromeBiologyVirusShrimpLipid dropletAutophagyVirologyViral replicationLipid metabolismMicrobiologyCell biologyBiochemistryFisheryApoptosisAutophagy in Disease and TherapyInvertebrate Immune Response MechanismsMosquito-borne diseases and control