Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
В. Н. Кошелев, Olga V. Primerova, Stepan V. Vorobyev, Л. В. Иванова
Abstract
A series of benzotriazole, cyclic amides and pyrimidine derivatives, containing 2,6-di-tert-butyl-phenol fragments, were synthesized. The redox properties of obtained compounds were studied using the cyclic voltammetry on a platinum electrode in acetonitrile. The oxidation potentials of all substances were comparable to those of BHT. The obtained compounds were tested for their antibacterial activity, and N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxoethyl)isatin (32 μg/mL) exerted good activity against Staphylococcus aureus.
Topics & Concepts
ChemistryIsatinAcetonitrileCyclic voltammetryRedoxBenzotriazolePhenolsAntibacterial activityPhenolPlatinumOrganic chemistryCombinatorial chemistryElectrochemistryElectrodeBacteriaPhysical chemistryBiologyCatalysisGeneticsSynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis of Organic Compounds