An <i>in vitro</i> study of lipase inhibitory peptides obtained from de-oiled rice bran
Titima Ketprayoon, Sajee Noitang, Papassara Sangtanoo, Piroonporn Srimongkol, Tanatorn Saisavoey, Onrapak Reamtong, Kiattawee Choowongkomon, Aphichart Karnchanatat
Abstract
value of 0.47 ± 0.02 μM. The Lineweaver-Burk plot revealed that FYLGYCDY is a non-competitive inhibitor, while analysis of the docking results provided details of the FYLGYCDY peptide binding site with the porcine pancreatic lipase (PPL) complex, which is a competitive type. It can be inferred from these findings that DORB may prove a useful raw material source for the production of anti-obesity peptides which might enhance the therapeutic and commercial performance of functional foods and healthcare products.
Topics & Concepts
LipaseBranIn vitroChemistryInhibitory postsynaptic potentialFood scienceBiochemistryEnzymeBiologyOrganic chemistryNeuroscienceRaw materialProtein Hydrolysis and Bioactive PeptidesEnzyme Catalysis and ImmobilizationMeat and Animal Product Quality