Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents
Lingfeng Liu, Chengcheng Kong, Marco Fumagalli, Karin Savková, Yiwen Xu, Stanislav Huszár, Josè Camilla Sammartino, Dongguang Fan, Laurent R. Chiarelli, Katarı́na Mikus̃ová, Zhaogang Sun, Chunhua Qiao
Topics & Concepts
ChemistryCovalent bondElectrophileNucleophileStereochemistryEnzymeAdductCombinatorial chemistryNitrosoWarheadChemical synthesisBiochemistryIn vitroOrganic chemistryCatalysisAerospace engineeringEngineeringBiochemical and Molecular ResearchCancer therapeutics and mechanismsCalcium signaling and nucleotide metabolism