Testosterone for Treating Female Sexual Dysfunction
James A. Simon, Kathleen M. Ohleth
Abstract
Testosterone levels vary throughout a woman's reproductive life, reaching their lowest level following menopause, and their nadir at about age 60, when they experience higher levels of sexual dysfunction. Testosterone improved the frequency of sexually satisfying events, desire, arousal, and orgasm in several randomized, controlled studies of surgically and naturally postmenopausal women. Available evidence from large cohort and registry studies does not show potentially concerning cardiovascular or breast safety signals with physiological levels of testosterone. Although no female testosterone products are currently approved in most of the world, one-tenth of the male dose can enhance female sexual function.