Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion
Laure Tillé, Daniela Cropp, Mélanie Charmoy, Patrick Reichenbach, Massimo Andreatta, Tania Wyss, Gabrielle Bodley, Isaac Crespo, Sina Nassiri, João Lourenço, M.M. Leblond, Cristina López‐Rodríguez, Daniel E. Speiser, George Coukos, Melita Irving, Santiago J. Carmona, Werner Held, Grégory Verdeil
Topics & Concepts
Tumor microenvironmentBiologyCD8Cytotoxic T cellTranscription factorCancer researchTumor necrosis factor alphaT cellImmunologyNFATCell biologyMolecular biologyImmune systemGeneticsGeneIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses