Sulfur stereogenic centers in transition-metal-catalyzed asymmetric C–H functionalization: generation and utilization
Wentan Liu, Jie Ke, Chuan He
Abstract
Transition-metal-catalyzed enantioselective C-H functionalization has emerged as a powerful tool for the synthesis of enantioenriched compounds in chemical and pharmaceutical industries. Sulfur-based functionalities are ubiquitous in many of the biologically active compounds, medicinal agents, functional materials, chiral auxiliaries and ligands. This perspective highlights recent advances in sulfur functional group enabled transition-metal-catalyzed enantioselective C-H functionalization for the construction of sulfur stereogenic centers, as well as the utilization of chiral sulfoxides to realize stereoselective C-H functionalization.
Topics & Concepts
StereocenterSurface modificationEnantioselective synthesisSulfurSulfoxideCatalysisStereoselectivityChemistryTransition metalCombinatorial chemistryStereochemistryOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques