Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects on <i>ESKAPE</i> Bacterial Pathogens
Josefine Eilsø Nielsen, Morgan A. Alford, Deborah Bow Yue Yung, Natalia Molchanova, John A. Fortkort, Jennifer S Lin, Gill Diamond, Robert E. W. Hancock, Håvard Jenssen, Daniel Pletzer, Reidar Lund, Annelise E. Barron
Abstract
pathogens compared with peptoids that form ellipsoidal or bundled assemblies. This is the first report of self-assembling peptoid antibacterials with activity against in vivo biofilm-like infections relevant to clinical medicine.
Topics & Concepts
AntimicrobialMicrobiologyComputational biologyBiologyAntimicrobial Peptides and ActivitiesChemical Synthesis and AnalysisPolydiacetylene-based materials and applications