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Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD

Youzhi Wang, Huifang Wang, Yang Guoqing, Qingjing Hao, Kan Yang, Hui-Zhen Shen, Yulong Wang, Jinxin Wang, Yulong Wang, Yulong Wang, Jinxin Wang

2023European Journal of Medicinal Chemistry11 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryAntioxidantPharmacologyRoflumilastPharmacophoreBifunctionalBiochemistryRolipramCOPDPhosphodiesteraseEnzymeMedicineInternal medicineCatalysisPhosphodiesterase function and regulationSynthesis and biological activitySynthesis of Organic Compounds
Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD | Litcius