NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model
Daniele Moretti, Sara Tambone, Mauro Cerretani, Paola Fezzardi, Antonino Missineo, Leticia-Toledo Sherman, Ignacio Munoz-Sajuan, Steven J. Harper, Celia Dominquez, Robert E. Pacifici, Licia Tomei, Larry Park, Alberto Bresciani
Topics & Concepts
KEAP1Oxidative stressHuntingtinSulforaphaneCell biologyTranscription factorDownregulation and upregulationReactive oxygen speciesNeurotoxicityChemistryHuntington's diseaseBiochemistryBiologyMolecular biologyGeneMutantToxicityMedicinePathologyOrganic chemistryDiseaseGenomics, phytochemicals, and oxidative stressCoenzyme Q10 studies and effectsPlant Stress Responses and Tolerance