An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3
Xu Wang, Lingyan Yan, Jihua Guo, Rong Jia
Topics & Concepts
ExonRNA splicingExonic splicing enhancerAlternative splicingExon skippingSplicing factorBiologyOligonucleotideMolecular biologyEnhancerMutationCancer researchChemistryGeneticsGeneGene expressionRNACancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesRNA modifications and cancer