Prognostic and chemotherapeutic response prediction by proliferation essential gene signature: Investigating POLE2 in bladder cancer progression and cisplatin resistance
Yu Liying, Na Lin, Yan Ye, Shuang Zhou, Yanjuan Xu, Jiabi Chen, Wei Zhuang, Qingshui Wang
Abstract
The PEG signature acts as a potential predictor for prognosis and chemotherapy response in BLCA patients. POLE2 is a key PEG and plays a remarkable role in promoting the malignant progression and cisplatin resistance of BLCA.
Topics & Concepts
Gene knockdownGene signatureCancer researchBladder cancerBiologyMalignancyCancerChemotherapyOncologyMedicineGeneGene expressionGeneticsBladder and Urothelial Cancer TreatmentsFerroptosis and cancer prognosisCancer, Lipids, and Metabolism