The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies.
Asumi Yokota, Li Huo, Fengli Lan, Jianqiang Wu, Gang Huang
Abstract
mutations, and potential therapeutic strategies to target RUNX1-mutated cases of hematological malignancies.
Topics & Concepts
RUNX1Myelodysplastic syndromesChronic myelomonocytic leukemiaGermline mutationPlatelet disorderLeukemiaGermlineMedicineCancer researchHaematopoiesisMyeloproliferative neoplasmMyeloid leukemiaMyeloidBone marrowSomatic cellMutationImmunologyBiologyMyelofibrosisGeneticsStem cellGenePlateletAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia researchRetinoids in leukemia and cellular processes