Platinum(II) Metallatriangle: Construction, Coassembly with Polypeptide, and Application in Combined Cancer Photodynamic and Chemotherapy
Yue Zhang, Xin Yan, Ling Shi, Moupan Cen, Jin Wang, Yue Ding, Yong Yao
Abstract
The development of the supramolecular coordination complex with different shapes and dimensionalities lays the basis for its application in different areas. In this study, a porphyrin-based 3D organo-Pt(II) metallatriangle (MTA) was fabricated through the reported method termed as “coordination driven self-assembly”. 31P NMR, 1H NMR, HR-MS, and theoretical calculation were employed to characterize the resultant MTA fully. Furthermore, the fabricated nanocomposite through coassembly of MTA and an amphiphilic polypeptide (PEG-PPT) could generate singlet oxygen (1O2) under the NIR irradiation and release a Pt drug under a low-pH microenvironment. 1O2 and the Pt drug can both damage the cancer cells, which improves the efficiency of cancer therapies. The fabrication of a Pt–porphyrin metallatriangle expands the topological structures, and the Pt–porphyrin metallatriangle can be applied to the combined cancer therapies. Moreover, various stimuli-responsive groups can be modified to the triangle, so a new method is created to develop high-performance biosupramolecular materials.