The cytochrome <i>bc</i><sub>1</sub> complex as an antipathogenic target
Nicholas Fisher, Brigitte Meunier, Giancarlo A. Biagini
Abstract
The cytochrome bc 1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum , which causes human malaria. Cytochrome bc 1 is an enzyme that contains two (ubi)quinone/quinol‐binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc 1 , and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.
Topics & Concepts
Coenzyme Q – cytochrome c reductaseCytochromeMode of actionCytochrome cPlasmodium falciparumCytochrome bMechanism of actionBiologyCytochrome P450BiochemistryRespiratory chainMitochondrionMalariaChemistryMicrobiologyEnzymeMitochondrial DNAGeneImmunologyIn vitroCancer therapeutics and mechanismsFungal Plant Pathogen ControlMicrobial Natural Products and Biosynthesis