Modeling the physiological roles of the heart and kidney in heart failure with preserved ejection fraction during baroreflex activation therapy
John S. Clemmer, W. Andrew Pruett
Abstract
Treatments that are efficacious in patients with HFrEF have not shown a significant impact on cardiovascular mortality in patients with HFpEF. We believe these simulations offer novel insight into the important roles of the cardiac and renal nerves in HFpEF and the potential mechanisms of how baroreflex activation alleviates HFpEF disease progression.
Topics & Concepts
BaroreflexMedicineCardiologyInternal medicineHeart failureEjection fractionHeart failure with preserved ejection fractionBlood pressureDiastoleCardiac function curveStroke volumeHeart rateHeart Rate Variability and Autonomic ControlHeart rate and cardiovascular healthCardiovascular Function and Risk Factors