Discovery of novel, potent, and orally bioavailable HDACs inhibitors with LSD1 inhibitory activity for the treatment of solid tumors
Ying‐Chao Duan, Tong Yu, Linfeng Jin, Shaojie Zhang, Xiaojing Shi, Yizhe Zhang, Nanqian Zhou, Yongtao Xu, Wenfeng Lu, Huimin Zhou, Huijuan Zhu, Suping Bai, Kua Hu, Yuanyuan Guan
Topics & Concepts
ChemistryPharmacologyHDAC1IC50In vivoTolerabilityEpigeneticsPotencyCancerDemethylaseCancer cellApoptosisCancer researchHistone deacetylaseBiochemistryHistoneIn vitroMedicineInternal medicineBiologyAdverse effectBiotechnologyGeneHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationProtein Degradation and Inhibitors