Hydrogen sulfide production does not affect antibiotic resistance in <i>Pseudomonas aeruginosa</i>
Lorenzo Caruso, Marta Mellini, Ortensia Catalano Gonzaga, Alessandra Astegno, Elena Forte, Adele Di Matteo, Alessandro Giuffrè, Paolo Visca, Francesco Imperi, Livia Leoni, Giordano Rampioni
Abstract
ABSTRACT Hydrogen sulfide (H 2 S) has been proposed to protect bacteria from antibiotics, pointing to H 2 S-producing enzymes as possible targets for the development of antibiotic adjuvants. Here, MIC assays performed with Pseudomonas aeruginosa mutants producing altered H 2 S levels demonstrate that H 2 S does not affect antibiotic resistance in this bacterium. Moreover, correlation analyses in a large collection of P. aeruginosa cystic fibrosis isolates argue against the protective role of H 2 S from antibiotic activity during chronic lung infection.
Topics & Concepts
Pseudomonas aeruginosaAntibioticsMicrobiologyAntibiotic resistanceBacteriaHydrogen sulfideCystic fibrosisBiologyChemistryGeneticsSulfurOrganic chemistryPharmaceutical and Antibiotic Environmental ImpactsAntibiotic Resistance in BacteriaAdvanced Chemical Sensor Technologies