Selective Para‐C−H Alkynylation of Aniline Derivatives by Pd/S,O‐Ligand Catalysis
Kezuan Deng, Wen‐Liang Jia, M. Ángeles Fernández‐Ibáñez
Abstract
Herein, we report a nondirected para-selective C-H alkynylation of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild conditions and is compatible with a variety of substituted anilines. The scalability and further derivatizations of the alkynylated products have been also demonstrated.
Topics & Concepts
AnilineAlkynylationChemistryLigand (biochemistry)CatalysisCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryReceptorBiochemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions