The Role of Integration Host Factor in Escherichia coli Persister Formation
Samantha Nicolau, Kim Lewis
Abstract
Persisters are phenotypic variants that survive exposure to antibiotics through temporary dormancy. Mutants with increased levels of persisters have been identified in clinical isolates, and evidence suggests these cells contribute to chronic infections and antibiotic treatment failure.
Topics & Concepts
Escherichia coliHost (biology)MicrobiologyMultidrug toleranceHost factorBiologyChemistryBacteriaVirologyBiofilmGeneticsGeneVirusBacterial Genetics and BiotechnologyEscherichia coli research studiesMicrobial Metabolic Engineering and Bioproduction