Tumor targeted alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX
Katherine A. Morgan, Christian Wichmann, Laura D. Osellame, Zhipeng Cao, Nancy Guo, Andrew M. Scott, Paul S. Donnelly
Abstract
Alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX leads to a highly significant therapeutic response in a mouse xenograft model.
Topics & Concepts
Carbonic anhydraseAlpha (finance)ChemistryAntibodyRadiochemistryAlpha particleBiochemistryEnzymeMedicinePhysicsImmunologyNuclear physicsNursingPatient satisfactionConstruct validityEnzyme function and inhibitionRadiopharmaceutical Chemistry and ApplicationsChemical Reactions and Isotopes