Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2
Ahmed H. Tantawy, Xiang‐Gao Meng, Adel A. Marzouk, Ali Fouad, Ahmed H. Abdelazeem, Bahaa G. M. Youssif, Hong Jiang, Man‐Qun Wang
Abstract
C-pocket. Collectively, these findings would contribute significantly to better understanding the Sirt-2 inhibitory mechanism in order to develop a new generation of refined and selective Sirt-2 inhibitors.
Topics & Concepts
PiperineResveratrolChemistryHybridPharmacologyTraditional medicineCombinatorial chemistryComputational biologyBiochemistryBiologyMedicineBotanySirtuins and Resveratrol in MedicinePiperaceae Chemical and Biological StudiesCalcium signaling and nucleotide metabolism