Litcius/Paper detail

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

Liwei Zhou, Shujia Qiao, Fengru Zhou, Xinyu Xuchen, Guobo Deng, Yuan Yang, Yun Liang

2021Organic Letters45 citationsDOI

Abstract

-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

Topics & Concepts

ChemistryDecarboxylationAlkeneIntramolecular forceCatalysisPalladiumCascadeArylCombinatorial chemistryCascade reactionStereochemistryOrganic chemistryAlkylChromatographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods