Alternative splicing of the bicistronic gene molybdenum cofactor synthesis 1 (MOCS1) uncovers a novel mitochondrial protein maturation mechanism
Simon Julius Mayr, Juliane Röper, Günter Schwarz
Abstract
produces two functional proteins, MOCS1A and MOCS1B, which follow different translocation routes before mitochondrial matrix import for cPMP biosynthesis involving both proteins. MOCS1 protein maturation provides a novel alternative splicing mechanism that ensures the coordinated mitochondrial targeting of two functionally related proteins encoded by a single gene.
Topics & Concepts
ExonMolybdenum cofactorRNA splicingBiologyAlternative splicingMitochondrionBiochemistryGeneCell biologyMolecular biologyBiosynthesisRNAMetalloenzymes and iron-sulfur proteinsRNA modifications and cancerMitochondrial Function and Pathology