CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter
Hen Prizant, Nilesh Patil, Seble G. Negatu, Noor Bala, Alexander I. McGurk, Scott A. Leddon, Angela Hughson, Tristan D. McRae, Yu‐Rong Gao, Alexandra M. Livingstone, Joanna R. Groom, Andrew D. Luster, Deborah J. Fowell
Abstract
clusters act as initial peripheral activation niches, optimizing controlled activation broadly throughout the tissue by coupling Th1 tissue entry with enhanced opportunities for Th1-APC encounter.
Topics & Concepts
PeripheralCell biologyNicheChemistryCXCL10BiologyImmunologyChemokineMedicineBiochemistryInternal medicineImmune systemImmunotherapy and Immune ResponsesChemokine receptors and signalingImmune Cell Function and Interaction