Kinetic Rationalization of Nonlinear Effects in Asymmetric Catalytic Cascade Reactions under Curtin–Hammett Conditions
Camran Ali, Donna G. Blackmond, Jordi Burés
Abstract
from what would be expected based on a linear relationship with the enantiopure catalyst. The treatment accounts for either positive or negative nonlinear effects in systems over a wide range of conditions including "major-minor" kinetics or the more conventional "lock-and-key" kinetics. The mechanistic scenario proposed here may apply generally to other cascade reaction systems exhibiting similar kinetic features and should be considered as a viable alternative model whenever a nonlinear effect is observed in a cascade sequence of reactions.
Topics & Concepts
CascadeChemistryCatalysisEnantioselective synthesisKinetic resolutionEnantiopure drugKineticsCascade reactionEnantiomerCombinatorial chemistryStereochemistryComputational chemistryOrganic chemistryPhysicsChromatographyQuantum mechanicsAsymmetric Synthesis and CatalysisAxial and Atropisomeric Chirality SynthesisAsymmetric Hydrogenation and Catalysis