Synthesis and biological evaluation of amide derivatives of isoxazole-imidazo[2,1-b]thiazole as anticancer agents
Krishna Babu Alapati, Dasari Sravani, B. B. V. Sailaja, B. Saritha, Somaiah Nalla
Abstract
A new series of amide functionality contained isoxazole-imidazo[2,1-b]thiazole (12a-j) were synthesized and their structures were characterized by analytical techniques. Further, all of the newly developed compounds 12a-j was assessed in vitro anticancer properties against a panel of four human cancer cell lines such as human breast cancer (MCF-7), human lung cancer (A549), human colon cancer (Colo-205) & human ovarian cancer (A2780) by using of MTT method. According to the results most of the compounds displayed good to moderate anticancer activity when compare with etoposide, which is used as positive control. Five compounds 12a, 12b, 12c, 12d and 12e showed most promising activities. Particularly, compound 12a displayed good activity on four cell lines.