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Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries

Yucen Tao, Xia Hao, Lanlan Jing, Lin Sun, Srinivasulu Cherukupalli, Shu-Gong Liu, Gaochan Wu, Shujing Xu, Xujie Zhang, Xiaoyu Shi, Yuning Song, Xinyong Liu, Peng Zhan

2021Bioorganic Chemistry26 citationsDOI

Topics & Concepts

ChemistryCDC25AIC50Cdc25Small moleculeDrug discoveryCombinatorial chemistryPhosphataseStereochemistryEnzymeBiochemistryCell cycleCell cycle checkpointCellIn vitroCyclin-dependent kinase 1Chemical Synthesis and AnalysisPeptidase Inhibition and AnalysisBiochemical and Molecular Research
Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries | Litcius