Enantioselective Selenol-ene Using Rh-Hydride Catalysis
Hannah S. Slocumb, Shao‐Zhen Nie, Vy M. Dong, Xiao‐Hui Yang
Abstract
This study showcases the first enantioselective hydroselenation of styrenes. Organoselenium building blocks are accessed with selectivity for the branched isomer. Through a Rh-hydride pathway, C-Se bonds can be forged with excellent regio- and enantiocontrol.
Topics & Concepts
ChemistryEnantioselective synthesisHydrideSelectivityEne reactionCatalysisOrganic chemistryCombinatorial chemistryMedicinal chemistryMetalOrganoboron and organosilicon chemistryOrganoselenium and organotellurium chemistryCatalytic Cross-Coupling Reactions