Reduced graphene oxide-coated electrospun fibre: effect of orientation, coverage and electrical stimulation on Schwann cells behavior
Zhiqiang Huang, Manman Sun, Yanyi Li, Zhenzhao Guo, Hong Li
Abstract
. When Schwann cells were seeded on the scaffolds and stimulated by 10 mV in vitro, it was found that either the alignment of the fibers or ES led to a higher level of proliferation and nerve growth factor (NGF) expression of Schwann cells. Further, ES at the aligned fibrous topography enhanced the expression of NGF, the proliferation of Schwann cells, and enhanced the cell migration rate by more than 60% compared to either ES or the oriented fibers alone. The application of exogenous electric cues mediated by templated biomaterials provides profound insights for nerve regeneration.
Topics & Concepts
Materials scienceGrapheneElectrospinningPolycaprolactoneSchwann cellRegeneration (biology)NanofiberNanotechnologyBiophysicsBiomedical engineeringComposite materialCell biologyBiologyPolymerMedicineNerve injury and regenerationGraphene and Nanomaterials ApplicationsTranscranial Magnetic Stimulation Studies