Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex
Nihal A. Salem, Amanda H. Mahnke, Kranti Konganti, Andrew Hillhouse, Rajesh C. Miranda
Abstract
, and other upstream regulators of differentially expressed genes and inhibited several autism-linked genes, suggesting that neurodevelopmental disorders share underlying mechanisms. PAE females exhibited neural loss of X-inactivation, with correlated activation of autosomal genes and evidence for spliceosome dysfunction. Thus, episodic PAE persistently alters the developing neural transcriptome, contributing to sex- and cell-type-specific teratology.
Topics & Concepts
BiologyTranscriptomeCerebral cortexNeurogenesisCell typeFetusNeurodevelopmental disorderEpigeneticsWnt signaling pathwayNeural cellNeural stem cellGeneGene expressionCellNeuroscienceCell biologyGeneticsPregnancyStem cellBirth, Development, and HealthPrenatal Substance Exposure EffectsPregnancy and preeclampsia studies