The structural heterogeneity of α-synuclein is governed by several distinct subpopulations with interconversion times slower than milliseconds
Jiaxing Chen, Sofia Zaer, Paz Drori, Joanna Zamel, Khalil Joron, Nir Kalisman, Eitan Lerner, Nikolay V. Dokholyan
Topics & Concepts
Förster resonance energy transferMonomerChemistryOligomerBiophysicsFibrilMolecular dynamicsCircular dichroismConformational changeConformational ensemblesIntrinsically disordered proteinsCrystallographyFluorescenceStereochemistryPolymerComputational chemistryBiochemistryBiologyPhysicsQuantum mechanicsOrganic chemistryParkinson's Disease Mechanisms and TreatmentsAdvanced Fluorescence Microscopy TechniquesAlzheimer's disease research and treatments