Multiple regulatory mechanisms, functions and therapeutic potential of chaperone-mediated autophagy
Yuhan Wang, Jingwei Liu, Hao Wang, Pengcheng Jiang, Liangzi Cao, Songming Lu, Siyi Zhang, Ruohan Yang, Hao Feng, Liu Cao, Xiaoyu Song
Abstract
Autophagy refers to the proteolytic degradation of cytoplasmic components by lysosomes, and includes three defined types: macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy. Although the regulatory pathways of macroautophagy are well defined, how CMA is accurately regulated remains less understood. In recent years, emerging evidence has suggested that chaperone-mediated autophagy is regulated by multiple mechanisms at nucleic acid and protein levels. In this review, we summarized recent progress on multiple regulatory mechanisms and functions concerning CMA, as well as novel treatments targeting specific regulation sites.