Palladium/Xu-Phos-catalyzed asymmetric carboamination towards isoxazolidines and pyrrolidines
Yuzhuo Wang, Lei Wang, Mingjie Chen, Youshao Tu, Yu Liu, Junliang Zhang
Abstract
The new chiral ligand (<italic>S</italic>,<italic>Rs</italic>)-<bold>Xu4</bold> with <italic>ortho</italic>-O<sup>i</sup>Pr showed good performance in the asymmetric carboamination reaction of <italic>N</italic>-Boc-<italic>O</italic>-homoallyl-hydroxylamines and <italic>N</italic>-Boc-pent-4-enylamines with aryl or alkenyl bromides.
Topics & Concepts
Enantioselective synthesisPalladiumCatalysisChemistryYield (engineering)PhosSubstrate (aquarium)Ligand (biochemistry)ArylCombinatorial chemistryReaction conditionsKinetic resolutionMedicinal chemistryOrganic chemistryReceptorMaterials scienceAlkylGeologyMetallurgyBiochemistryOceanographyCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and Catalysis