Cobalt-Catalyzed Enantioselective Hydrogenation of Diaryl Ketones with Ferrocene-Based Secondary Phosphine Oxide Ligands
Liyao Zeng, Menglong Zhao, Bijin Lin, Jingyuan Song, James H. R. Tucker, Jialin Wen, Xumu Zhang
Abstract
A new class of cobalt catalytic system for asymmetric hydrogenation of ketones was herein reported, involving the development of novel ferrocene-based secondary phosphine oxide ligands. An unusual P–O bidentate coordination pattern with cobalt was confirmed by an X-ray diffraction study. The bichelating tetrahedral cobalt(II) complexes afforded high reactivities (up to 99% yield) and good to excellent enantioselectivities (up to 92% ee) in the AH of various ortho -substituted diaryl ketones. In addition, the diferrocenyl cobalt complex was characterized with intriguing UV–vis absorption and electrochemical properties.
Topics & Concepts
ChemistryCobaltFerroceneCatalysisDenticityPhosphinePhosphine oxideEnantioselective synthesisElectrochemistryYield (engineering)Asymmetric hydrogenationCobalt oxideMedicinal chemistryOrganic chemistryCrystal structureElectrodeMaterials sciencePhysical chemistryMetallurgyAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisCatalysis for Biomass Conversion