<scp>Iron‐Catalyzed</scp> Amide Bond Formation from Carboxylic Acids and Isocyanates<sup>†</sup>
Lingjian Zi, Jing Zhang
Abstract
Comprehensive Summary We describe an iron‐catalyzed amide bond formation from readily available carboxylic acids and isocyanates. This method utilizes an abundant and biocompatible iron catalyst and easily accessible starting materials, generates CO 2 as the only byproduct, and features broad substrate scopes with good functional group compatibility. Therefore, it provides a cost‐effective and practical protocol to access a diverse variety of amides.
Topics & Concepts
ChemistryAmideCatalysisSubstrate (aquarium)Functional groupCombinatorial chemistryPeptide bondCarboxylic acidBiocompatible materialOrganic chemistryPolymer chemistryEnzymeMedicineBiomedical engineeringOceanographyGeologyPolymerAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAdvanced Synthetic Organic Chemistry