LncRNA LOC100129620 promotes osteosarcoma progression through regulating CDK6 expression, tumor angiogenesis, and macrophage polarization
Yong Chen, Guoqing Tang, Hongbin Qian, Ji Chen, Bing Cheng, Chengliang Zhou, Yixin Shen
Abstract
. LOC100129620 can bind to miR-335-3p and regulate its function. MiR-335-3p mediates the regulatory effects of LOC100129620 on CDK6. LOC100129620 promotes the formation of blood vessels and the polarization of macrophages. The LOC100129620/miR-335-3p/CDK6 signaling pathway promotes the metastasis of osteosarcoma by regulating the proliferation of osteosarcoma cells, angiogenesis, and macrophage polarization.
Topics & Concepts
AngiogenesisMacrophage polarizationOsteosarcomaCancer researchCyclin-dependent kinase 6Tumor progressionMacrophageMedicineBiologyInternal medicineCyclin D1CancerCell cycleIn vitroGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA modifications and cancer