The clinical spectrum of primary lateral sclerosis
Richard J. Barohn, John K. Fink, Terry Heiman‐Patterson, Edward D. Huey, Jennifer Murphy, Jeffrey Statland, Martin R. Turner, Lauren Elman
Abstract
Primary lateral sclerosis is a distinct entity that has recently been classified as a "restricted phenotype" of ALS. It is characterized by a pattern of isolated upper motor neuron involvement that often begins in the legs and spreads diffusely. Distinction from other conditions requires careful consideration of clinical presentation and time course of disease. Mills' Syndrome is a rare unilateral variant of primary lateral sclerosis. Cognitive and behavioral involvement may occur.
Topics & Concepts
Multiple sclerosisPrimary (astronomy)NeurosciencePresentation (obstetrics)DiseaseMedicineCognitionPhysical medicine and rehabilitationPsychologyPathologyPsychiatrySurgeryPhysicsAstronomyAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchHereditary Neurological Disorders