Loss of KMT2C reprograms the epigenomic landscape in hPSCs resulting in NODAL overexpression and a failure of hemogenic endothelium specification
Shailendra S. Maurya, Wei Yang, Minori Tamai, Qiang Zhang, Petra Erdmann-Gilmore, Amelia Bystry, Fernanda Martins Rodrigues, Mark C. Valentine, Winghing Wong, Reid Townsend, Todd E. Druley
Abstract
hemogenic endothelium specification. These unbiased multi-omic results provide new evidence for germline mechanisms increasing risk of early leukaemogenesis.
Topics & Concepts
BiologyGermlineEpigeneticsGeneticsEpigenomicsCancer researchSomatic cellEpigenomeDNA methylationCell biologyGeneGene expressionEpigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer Genomics and Diagnostics