Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents
Fei Xie, Tingjunhong Ni, Zichao Ding, Yumeng Hao, Ruina Wang, Ruilian Wang, Ting Wang, Xiaoyun Chai, Shichong Yu, Yongsheng Jin, Yuanying Jiang, Dazhi Zhang
Topics & Concepts
Candida albicansChemistryFluconazoleIsoxazoleIn vitroAntifungalMinimum inhibitory concentrationDocking (animal)StereochemistryEnzymeTriazoleCYP3A4Combinatorial chemistryBiochemistryMicrobiologyOrganic chemistryBiologyCytochrome P450NursingMedicineAntifungal resistance and susceptibilitySynthesis and Biological EvaluationFungal Infections and Studies