Electrochemical Dearomatization of Indoles: Access to Diversified Fluorine-Containing Spirocyclic Indolines
Kangdong Mo, Xiaocong Zhou, Ju Wu, Yufen Zhao
Abstract
A robust and green electrochemical dearomatization of indoles was developed by merging a fluorine-containing group to an indole nucleus under oxidant-free conditions, delivering a diverse array of tri- and difluoromethylated 3,3-spiroindolines with good functional group tolerance.
Topics & Concepts
ChemistryIndole testElectrochemistryFluorineCombinatorial chemistryFunctional groupGroup (periodic table)NucleusOrganic chemistryElectrodePhysical chemistryPolymerCell biologyBiologyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions