Highly enantioselective Ni-catalyzed asymmetric hydrogenation of β,β-disubstituted acrylic acids
Guiying Xiao, Chaochao Xie, Qian‐Ling Guo, Guofu Zi, Guohua Hou, Yuping Huang
Abstract
A highly enantioselective Ni-catalyzed hydrogenation of β,β-disubstituted acrylic acids was first realized using Ph-BPE, providing straightforward access to chiral carboxylic acids in high yields with excellent enantioselectivities, up to 99% ee.
Topics & Concepts
Enantioselective synthesisChemistryCatalysisAcrylic acidOrganic chemistryAsymmetric hydrogenationCombinatorial chemistryCopolymerPolymerAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisAsymmetric Synthesis and Catalysis