Porcine Epidemic Diarrhea Virus Inhibits HDAC1 Expression To Facilitate Its Replication via Binding of Its Nucleocapsid Protein to Host Transcription Factor Sp1
Jidong Xu, Junyong Mao, Xiao Han, Fushan Shi, Qin Gao, Tingjun Wang, Zhen‐Ning Zhang, Ying Shan, Weihuan Fang, Xiaoliang Li
Abstract
The enteric coronavirus porcine epidemic diarrhea virus (PEDV) causes fatal acute intestinal infection in neonatal pigs that rely on innate immune responses. Histone deacetylases (HDACs) play important roles in innate immune regulation. Our study found PEDV suppresses HDAC1 expression via the interaction of its N protein and porcine Sp1, which identified a novel mechanism of PEDV evasion of the host responses to benefit its replication. This study suggests that other coronaviruses, including SARS-CoV and SARS-CoV-2, also make use of their N proteins to intercept the host immune responses in favor of their infection.
Topics & Concepts
BiologyPorcine epidemic diarrhea virusInnate immune systemVirologyVirusImmune systemCoronavirusViral replicationTranscription factorHistoneDiarrheaHost factorImmunologyGeneticsGeneInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)DiseaseInternal medicineMedicinePathologyVirus-based gene therapy researchHistone Deacetylase Inhibitors ResearchRNA Interference and Gene Delivery