The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models
Rui Caetano Oliveira, Ana Margarida Abrantes, José Guilherme Tralhão, Maria Filomena Botelho
Abstract
Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new therapeutic targets. In order to accomplish that, the animal models must replicate the clinical evolution of the disease in all of its phases. In this article, we review the existent mouse models, with their strengths and weaknesses in the replication of human cancer disease progression, with major focus on orthotopic models.
Topics & Concepts
Colorectal cancerDiseaseCancerReplicateStrengths and weaknessesAnimal modelMedicineReplication (statistics)BioinformaticsIntensive care medicineBiologyPathologyPsychologyInternal medicineVirologyMathematicsSocial psychologyStatisticsCancer Research and TreatmentsCancer Cells and MetastasisCancer, Stress, Anesthesia, and Immune Response