Doxorubicin Conjugation to Reovirus Improves Oncolytic Efficacy in Triple-Negative Breast Cancer
Jameson Berry, Luis E. Muñoz, Roxana M. Rodríguez Stewart, Periasamy Selvaraj, Bernardo A. Mainou
Abstract
, with greater reduction in metastatic burden after reo-dox inoculation. Together, these data demonstrate that crosslinking chemotherapeutic agents to oncolytic viruses facilitates functional drug delivery to cells targeted by the virus, making it a viable approach for combination therapy against TNBC.
Topics & Concepts
Oncolytic virusDoxorubicinTriple-negative breast cancerBreast cancerCancer researchMetastatic breast cancerMedicineCancerImmunologyChemotherapyOncologyVirologyInternal medicineVirus-based gene therapy researchViral gastroenteritis research and epidemiologyCancer Research and Treatments