Enantioselective Synthesis of Atropisomers with Multiple Stereogenic Axes
Xiaoze Bao, Jean Rodriguez, Damien Bonne
Abstract
Abstract Atropisomers possessing multiple stereogenic axes are intriguing molecules with huge potential. However, only few approaches for their enantioselective synthesis are available due to the difficulties in assembling various stereogenic axes with high enantiocontrol. Only recently, innovative methods have emerged, opening new possibilities for the synthesis of this original class of atropisomeric compounds. This Minireview describes the development of this field based on a classification of the multi‐axis systems according to the distance between the stereogenic axes and the strategy used to build them.
Topics & Concepts
StereocenterAtropisomerEnantioselective synthesisTopology (electrical circuits)StereochemistryChemistryMathematicsCombinatoricsCatalysisOrganic chemistryAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis