Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1–42 through Nrf2/HO-1 and NF-κB signaling pathway in mice
Shiyu Jin, Xin Wang, Xiaotong Xiang, Yumei Wu, Jie Hu, Yueyue Li, Yue Lin Dong, YueQiang Tan, Xian Wu
Topics & Concepts
CangrelorNeurotoxicityNeuroinflammationMicrogliaPharmacologyOxidative stressSuperoxide dismutaseHippocampusMedicineChemistryInflammationInternal medicineToxicityConventional PCIPrasugrelMyocardial infarctionAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders