An expedient synthesis of novel spiro[indenoquinoxaline-pyrrolizidine]-pyrazole conjugates with anticancer activity from 1,5-diarylpent-4-ene-1,3-diones through the 1,3-dipolar cycloaddition/cyclocondensation sequence
Nikolay S. Zimnitskiy, Alexey Yu. Barkov, Maria V. Ulitko, Igor B. Kutyashev, Vladislav Yu. Korotaev, Vyacheslav Ya. Sosnovskikh
Abstract
A highly regio- and stereoselective two-stage route for the synthesis of spiro[indenoquinoxaline-pyrrolizidine]-pyrazole hybrids with anticancer activity has been developed.
Topics & Concepts
ChemistryPyrrolizidinePyrazoleEne reactionCycloadditionStereoselectivityStereochemistrySequence (biology)ConjugateOrganic chemistryBiochemistryCatalysisMathematical analysisMathematicsSynthesis and Biological EvaluationSynthesis and biological activityBioactive Compounds and Antitumor Agents