Allosteric GABAA Receptor Modulators—A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility
Blanca Angelica Vega Alanis, Maria Teresa Iorio, Luca Silva, Konstantina Bampali, Margot Ernst, Michael Schnürch, Marko D. Mihovilovič
Abstract
GABAA receptor modulators are structurally almost as diverse as their target protein. A plethora of heterocyclic scaffolds has been described as modulating this extremely important receptor family. Some made it into clinical trials and, even on the market, some were dismissed. This review focuses on the synthetic accessibility and potential for library synthesis of GABAA receptor modulators containing at least one heterocyclic scaffold, which were disclosed within the last 10 years.
Topics & Concepts
GABAA receptorAllosteric regulationAllosteric modulatorReceptorGABAA-rho receptorComputational biologyChemistryPharmacologyBiochemistryBiologyNeuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyPharmacological Receptor Mechanisms and Effects